Pre-Clinical SIG (previously TOX SIG) 

 

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Core Committee (L-R): Fetene Tekle (Janssen), Gareth Thomas (former member and chair), Bernd Igl (Boehringer Ingelheim), Eloisa Brook (chair, GlaxoSmithKline), Jim Saul (former member, Covance) and Phillip Jarvis (former member, Novartis). Luc Essermeant (Sanofi), Ezgi Tanriver-Ayder (GlaxoSmithKline), Sarah Vandepaer (GlaxoSmithKline), Dorothee Tamarelle (Sanofi) and Denise Federico (Evotec) have also joined the team.

 

Objectives

To provide a forum to discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment and to promote the involvement of Statisticians in these areas.

Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in preclinical (animal and cell based experiments) areas such as:

- Discovery

- Good statistical practice in in-vitro, ex-vivo and in-vivo assay development

- Reproducibility and Translation from pre-clinical to clinical

- Toxicogenomics

- Genetic Toxicology
- Acute Toxicology
- General Toxicology

- Eco-Toxicology
- Toxicokinetics
- DMPK / Pharmacokinetics
- ECG
- Immuno Toxicology
- Histopathology
- Pharmacology
- Developmental and Reproductive Toxicology

- Carcinogenicity

 

We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list. 

Find out more in our video overview:

 

Upcoming Pre-Clinical SIG 2024 Workshop

We're delighted to share that the Pre-Clinical SIG Workshop returns in 2024, taking place face-to-face in Paris, France. This event, split over two half-days, will cover topics including pre-clinical design of experiments & how to teach this; statistics and genetic toxicology; and the new and promising OMARS DOE and ANOVA-type.

Speakers

 

 

Though aimed especially at those working in pre-clinical, this event is open to all statisticians within the pharmaceutical industry, BUT, spaces are very limited, so be sure to secure your registration as soon as possible! The Early-Bird rates expire on Friday 22nd December, with full registration closing Wednesday 7th February 2024

Please kindly click through to read the full event details here and to register, please click here. We hope to see you there!

 

Webinars

The PSI Pre-Clinical Special Interest Group seminars for 2023 are as follows: 

Date

Title

Presenter

 

14 March 2023

End-user Tool for Immunogenicity Cut-points Calculation 

Dr. Els Pattyn, Ablynx

To access the video on demand, please click here

27 June 2023

EC50 Estimation based on Multi-Donor Dose-Response Data

Dr. Weiliang Qiu and Dr. Cheng Wenren, Sanofi

To access the video on demand, please click here
24 October 2023

Adjusting Experimental and Statistical Approaches throughout Preclinical Development Pathways

PD Dr. Ulf Tölch, Berlin Institute of Health at Charité



 

 

How to get in touch

Please email us with any questions or comments and if you would like to join our mailing list.


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