Pre-Clinical SIG (previously TOX SIG) 

 

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Core Committee (L-R): Fetene Tekle (Janssen), Gareth Thomas (Covance), Bernd Igl (Boehringer Ingelheim), Eloisa Brook (GlaxoSmithKline), Jim Saul (Covance) and Phillip Jarvis (Novartis). Natasha Karp (Astrazeneca) has also recently joined the SIG.

 

Objectives

To provide a forum to discuss and advance statistical topics related to Research, Discovery (including efficacy models), Regulatory and Investigative Toxicology/Safety Assessment and to promote the involvement of Statisticians in these areas.

 

Who we are

Our membership consists of statisticians at CROs, pharmaceutical companies and academia who are working in areas such as:

- Discovery

- Good statistical practice in in-vitro, ex-vivo and in-vivo assay development

- Reproducibility and Translation from pre-clinical to clinical

- Toxicogenomics

- Genetic Toxicology
- Acute Toxicology
- General Toxicology

- Eco-Toxicology
- Toxicokinetics
- DMPK / Pharmacokinetics
- ECG
- Immuno Toxicology
- Histopathology
- Pharmacology
- Developmental and Reproductive Toxicology

- Carcinogenicity

 

We discuss diverse topics ranging from Dog Telemetry data analysis to Decision Trees, from Bayesian methods to dealing with irate study directors, and now have a list of over 50 affiliates on our e-mail distribution list. 

Find out more in our video overview:

Upcoming Events

The PSI Pre-clinical Special Interest Group have a series of regular FREE webinars dealing with statistical topics faced in pre-clinical and related fields. The presentations will run for an hour, with approximately 45 min presentation and a Q&A session in the remaining time. See section below for details of this year’s webinars.

Webinars

The PSI Pre-Clinical Special Interest Group seminars for 2021 are as follows: 

Date

Title

Presenter

 Slides/Video on Demand

16 Mar

Beyond the looking glass – Interpreting animal welfare & behaviour by monitoring & assessing mice activity data

Eloisa Brook, Joanna Moore, George Birbeck. GSK

VoD

29 Jun

Update from the Carcinogenicity working group

Steve Bailey. Pfizer

VoD

12 Oct

Therioepistomology 

Dr Brianna Gaskill. Novartis

 

 

For all previous webinars click here.

Workshop

 

We are already planning for when we are able to hold face-to-face workshops again.  Watch this space. 

 

 


How to get in touch

Join our mailing list by e-mailing this address with brief details of the field(s) you are working in.

 


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Upcoming Events

PSI VisSIG Wonderful Wednesdays

Our monthly webinar explores examples of innovative data visualisations relevant to our day to day work. Each month a new dataset is provided from a clinical trial or other relevant example, and participants are invited to submit a graphic that communicates interesting and relevant characteristics of the data.

PSI Book Club

PSI are starting a book club! We will be reading/discussing non-technical books relevant to our roles. Participants will be split into smaller groups to network with each other and practice exercises.

PSI Vaccine & COVID-19 SIGs Joint Webinar: Statistics, Vaccine Development, and the COVID-19 Crisis

The first talk will be about "Introduction to Statistical Methods and Challenges in Vaccine Development" by Ivan Chan and the second talk will be about "Vaccine quintet. Statistical issues in the design and analysis of five vaccine programmes" by Stephen Senn.

PSI Training Course: Use of Historical Data in Clinical Trials: An Evidence Synthesis Approach

In this short course, we will provide a statistical framework to incorporate external information into a trial. Bayesian Dynamic Borrowing designs based on the meta-analytic predictive (MAP) model will be detailed, and a practice session will be proposed with applications using the R package RBesT.

PSI Medical Statistics Careers Event

Our annual PSI Medical Statistics Careers Event, will be held online on Wednesday 2nd March 2022. The event will include a live online panel discussion and a virtual exhibition session.

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