Video-on-Demand Library


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11 June 2025

This month it’s all about improving an existing plot from a recent publication on a hyperkalemia trial. Bodo Kirsch is leading the panel discussion on dos and don’ts of effective visualisations. All visualisations are available on the Wonderful Wednesday blog.

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The discussion touched various issues in scientific data visualisation, like messaging, axis limits, background grids and shading, interpolation, choice of legend, reference lines and explanatory text. This was followed by a demonstration of instant patient level data simulation using AI. The next challenge is to include these patient level data into the graphical display of the hyperkalemia trial results. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang, Lovemore Gakava and Aditeya Pandey

03 June 2025

A one hour webinar which explains the topic in the published paper, ‘Applying the Estimand Framework to Clinical Pharmacology Trials with a Case Study in Bioequivalance’

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Mark Baird, Helle Lynggaard, Sue McKendrick, David Wright

The expert authors of a recent paper introduce the game-changing concepts of the “estimand framework”, "intercurrent events", and the estimand thinking process. In this beginner-friendly session, you'll learn, step-by-step, how to apply estimand thinking to your trials, leading to clearer objectives and more meaningful results.   There is a practical case study – a bioequivalence trial – to illustrate how the estimand framework can eliminate ambiguity and bring greater transparency to the key clinical questions you're investigating. Beyond this specific example, there is discussion around the broader impact of estimands on various clinical pharmacology trials. 

27 May 2025

Success isn’t about making big changes—it’s about making small, consistent ones. James Clear’s bestselling book “Atomic Habits” reveals how tiny daily improvements compound into remarkable results, helping you break bad habits, build good ones, and unlock your full potential.

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Success isn’t about making big changes—it’s about making small, consistent ones. James Clear’s bestselling book “Atomic Habits” reveals how tiny daily improvements compound into remarkable results, helping you break bad habits, build good ones, and unlock your full potential.

The webinar will comprise of an introductory talk followed by discussion from participants to share their experiences and thoughts on the podcast (or the book). Together, we’ll explore how to practically apply the habits in our professional lives, share insights, and reflect on how these principles can enhance both our personal and professional journeys.

15 May 2025

As the current therapy of the Macrophage Activation Syndrome has significant side effects, dose reduction is key. Steve Mallet presents visualisations to effectively demonstrate the dose reduction over time, both on the individual level and in summary. All visualisations are available on the Wonderful Wednesday blog.

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The discussion of the various plots includes advantages of double coding, intelligent sorting, choosing time intervals, selecting suitable colour gradients and the level order. The latter one is important for streamgraphs, stacked bar charts and Sankey diagrams. The next challenge is to improve a plot on serum K reduction in hyperkalemia patients. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang, Lovemore 

06 May 2025

The speakers cover an introduction to oncology dose finding, discussing the FDA’s Project Optimus, model assisted methods, including BOIN, alongside the escalation package in R which provides a range of dose finding tools, including simulations and head-to-head comparison of methods.

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Overview

The speakers cover an introduction to oncology dose finding, discussing the FDA’s Project Optimus, model assisted methods, including BOIN, alongside the escalation package in R which provides a range of dose finding tools, including simulations and head-to-head comparison of methods. Recent dose optimisation approaches are discussed, including a dose comparison paradigm using U-MET (utility-based dose optimization approach for multiple-dose randomized trial designs) and U-DESPE (a Bayesian utility-based approach based on Dose-Exposure, Safety, Pharmacodynamics and Efficacy).

Speakers

Ayon Mukherjee; Michael Sweeting; Gina D'Angelo; Anaïs Andrillon; Pavel Mozgunov (Chair)

09 April 2025

Measuring treatment response is vital for the assessment of the efficacy of a drug. Visualisations can help to show response gain and maintenance or loss over time. Rhys Warham guides through pros and cons of various visualisations. Those are available on the Wonderful Wednesday blog.

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Animation of plots over time is a very intuitive way to show development of the results over the course of the study. Lasagna plots allow seeing individual patient data, but then right sorting is crucial. Sankey diagrams make it easy to compare proportions over time. This can also be achieved with stacked area charts with careful interpretation of the intermediate stages. The next challenge is on dose tapering. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang, Lovemore Gakava, Aditeya Pandey


24 March 2025

Webinar to give a brief introduction to AI, followed by a presentation of various applications in medicinal product lifecycle. Several aspects will be discussed incl. performance, theoretical and practical conditions and also regulatory guidelines.

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Artificial Intelligence (AI) is increasingly integrated into the development and regulation of medicinal products, offering new opportunities in drug discovery, clinical trials, and manufacturing. AI-driven approaches, particularly machine learning and bioinformatics, facilitate target identification, optimize patient selection in clinical trials, and enhance process control in pharmaceutical manufacturing. In the context of biomedicine, AI plays a critical role in predicting drug-target interactions, modelling peptide-MHC binding for immunotherapy, and improving the precision of CRISPR-Cas9 genome editing.

Despite its potential, AI applications in medicinal products present challenges, including data quality, algorithm validation, and regulatory compliance. The necessity for robust performance metrics and risk assessment frameworks is paramount to ensure the reliability and safety of AI-driven methodologies.

17 March 2025

The assessment of benefit and risk is in the centre of evaluating treatments. Lovemore Gakava and special guest Mike Colopy are discussing visual approaches to support this assessment. Visualisations are available on the Wonderful Wednesday blog.

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Very common displays for benefit-risk are forest plots on effect sizes. Those improve by adding information about rates or proportions and totals. The comparison of multiple treatments is easy with trade-off plots. A basic overview of benefits and risk is nicely show with a value tree. The next challenge is on Markov traces. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang, Lovemore 

11 March 2025

Get an insight into how maths is used to help develop experiments to test lifesaving medicines. This webinar showcases the different roles and pathways into the industry and we hear from a panel of professionals who share their experiences and answer your questions!

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Hosted by Emma Crawford, Katie Gwinnell, Alistair Haston, Tabitha Lennox, Oswald Dallimore, Sarah Crossley

Get an insight into how maths is used to help develop experiments to test lifesaving medicines. This webinar showcases the different roles and pathways into the industry and we hear from a panel of professionals who share their experiences and answer your questions!

19 February 2025

It is a real challenge to display adverse event data. There are a lot of different aspects to concentrate on. How this can be approached is presented by Bodo Kirsch. Visualisations are available on the Wonderful Wednesday blog.

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It is a real challenge to display adverse event data. There are a lot of different aspects to concentrate on. How this can be approached is presented by Bodo Kirsch. Visualisations are available on the Wonderful Wednesday blog
The time course of adverse events can be shown with violin plots. To explore the co-occurrence of events a visually enhanced correlation matrix is helpful. Various ways are presented to effectively combine (stacked) bar charts with induvial patient data display and violin plots to explore subgroup differences. The next challenge is on benefit-risk profiles. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang

08 January 2025

Looking back to a year of visualisations in healthcare with Rhys Warham. Visualisations are available on the Wonderful Wednesday blog.

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What is the best visualisation? That depends heavily on the purpose. For exploration interactive and animated plot are presented that enhance the understanding of the data. For explanation a static plot is best if it delivers the message on the first glance. The next challenge is on adverse event hierarchy. See the Wonderful Wednesday homepage for more detail.

Wonderful Wednesdays are brought to you by the Visualisation SIG. The Wonderful Wednesday team includes Bodo Kirsch, Zachary Skrivanek, Lorenz Uhlmann, Steve Mallett, Rhys Warham, Mark Baillie, Paolo Eusebi, Martin Brown, Benjamin Lang

12 December 2024

Andrew Grieve and Zhiwei Zhang present their recent work. With the webinar chaired by Jenny Devenport.

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Papers for discussion:

Andrew Grieve
: Probability of success and group sequential designs - https://onlinelibrary.wiley.com/doi/10.1002/pst.2346

Zhiwei Zhang, Carrie Nielson, Ching-Yi Chuo & Zhishen Ye: Information-based group sequential design for post-market safety monitoring of medical products using real world data - https://onlinelibrary.wiley.com/doi/10.1002/pst.2385
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