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25 June 2025

The iRISE (improving Reproducibility In SciencE) project aims to deepen our understanding of the drivers contributing to poor reproducibility and to conduct a detailed evaluation – including primary research – of the effectiveness of interventions to increase reproducibility. The project’s work package (WP) on theory is dedicated to clarifying terms and underlying concepts related to reproducibility. To ensure efficient communication within the iRISE consortium, we produced a glossary with working definitions of terms including reproducibility, replicability, and replication.  A concept important in pre-clinical drug discovery, translatability, was for example defined as "the ability to apply research discoveries from experimental models to applications that directly benefit humans".  The definitions are complemented with measures to quantify different types of reproducibility, and theories on the possible factors leading to irreproducibility.

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