Video-on-Demand Library

06 May 2025

Overview

The speakers cover an introduction to oncology dose finding, discussing the FDA’s Project Optimus, model assisted methods, including BOIN, alongside the escalation package in R which provides a range of dose finding tools, including simulations and head-to-head comparison of methods. Recent dose optimisation approaches are discussed, including a dose comparison paradigm using U-MET (utility-based dose optimization approach for multiple-dose randomized trial designs) and U-DESPE (a Bayesian utility-based approach based on Dose-Exposure, Safety, Pharmacodynamics and Efficacy).

Speakers

Ayon Mukherjee; Michael Sweeting; Gina D'Angelo; Anaïs Andrillon; Pavel Mozgunov (Chair)

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