Video-on-Demand Library

01 December 2020

Jenny Thomas, Chris Smith, Alice Hedge
The webinar will provide a general introduction to the topic of combining sexes for statistical analysis in Toxicology. It will also discuss guideline recommendations pertaining to this topic. For electrocardiography and jacketed external telemetry data, it will discuss scientific preferences, historical data review and statistical recommendations. For Developmental and Reproductive Toxicology endpoints, it will focus on neurobehavioral data. In these studies, the actual impact of sex on a given endpoint can be very much dependent on the age of the animals being tested. It is widely considered by scientists that very young animals may not demonstrate any differences due to sex. However, these tests are conducted at various stages in development so a statistical plan that accounts for potential sex differences, whilst still allowing for the additional power that may be observed from pooling the sexes is required.

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