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PSI Conference 2018: How large should the type I error be?

04 June 2018

Regulatory guidance says that α=5% is “conventional” but that alternative values “may be acceptable or even preferable in some cases”. Historically, the value 5% can be traced back to Fisher, who was clear that this is an arbitrary choice. In this presentation, we will try to optimize the Type I Error, based on a total public health perspective. We conclude that the Type I Error should be different for different clinical trials, reflecting the size of the trial and the rarity of the disease.

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