Small Populations SIG


The SIG “Small populations” provides a forum for identifying and discussing statistical methodology related to clinical development of treatments in small populations, and for sharing experiences.


Our objectives include:

  • Exchange information & share case studies of statistical/methodological challenges in the area of small populations
  • Collaborate and discuss strategies and methodology
  • Support the promotion of new methodology
  • Organise and/or participate in workshops in the area of small populations

Who we are

Andreas Kaiser (Co-chair)Bayer
Berlin, Germany
Aysun Cetinyurek YavuzDanone Nutricia ResearchUtrecht, Netherlands 
Carol ReidRocheWelwyn Garden City, UK
Francois Aubin (Co-chair)Venn Life SciencesParis, France
Frances LynnOrchard-TX 
Natacha GallotClinBAYFrance
Rafael SauterJohnson & JohnsonAllschwil, Switzerland
Tal OtikerGSKLondon, UK
Tim FriedeUniversity Medical Center GöttingenGöttingen, Germany


How to get in touch

For further information, or to join the Small Population SIG, please contact the co-chairs:

Andreas Kaiser (Bayer),

Francois Aubin (Venn Life Sciences),


The SIG Small Populations has been working to identify publications that would be useful for statisticians working in studies with small populations. The topics that were chosen as of interest were extrapolation, historical controls, and meta-analytic priors.

Subgroups were set up to work on each of these topics. A literature search was performed to identify publications of potential interest. These were then reviewed within the subgroups and those deemed most relevant and useful were identified. The attached slides list the publications recommended for each topic with a brief description of the content and the reason for the recommendation.

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