Date: Tuesday 4th October 2022 Time: 14:00-15:00 BST | 15:00-16:00 CEST Speaker: Brianna Gaskill (Novartis)
Who is this event intended for? Colleagues working in in-vivo research. What is the benefit of attending? Attendees have the opportunity to learn how knowledge can be gained from animal research.
Registration
You can now register for this event. Registration fees are as follows:
- Members of PSI = Free of charge
- Non-Members of PSI = Free of charge
To register for the session, please click here.
Overview
In recent years, the scientific community has finally become more generally aware of the current reproducibility and translatability crisis. Some of this awareness has come from the recent NIH initiative on “Enhancing rigor, transparency, and translatability in animal research” starting a paradigm shift around certain themes. This shift can be characterized at the micro level as a shift from asking “what have we controlled for in this model?” to asking “what have we chosen to ignore in this model, and at what cost?” At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study, this includes providing for an animals welfare as well as experimental design and analysis techniques. Colleagues and I feel that we are witnessing the birth of a new discipline, which we have termed Therioepistemology, or the study of how knowledge is gained from animal research. In this talk, I’ll outline six questions that help critically evaluate animal-based biomedical research from a therioepistemological perspective. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health, animal well-being, and scientific quality.
Speaker details
Speaker
Biography
Brianna Gaskill, PhD Novartis
Brianna received her BS from Kansas State University and PhD in Animal Behavior and Well-being from Purdue University. She completed a postdoctoral position at Charles River after graduation, then returned to Purdue as a faculty member in 2014 and was awarded tenure in 2020. Her research has focused on developing new animal welfare assessment methodologies, rodent well-being, and elucidating the scientific impact of welfare problems in animal based research. She recently started a new position at Novartis as their 3Rs scientist where she will work closely with disease area scientists to apply 3Rs strategies to improve animal welfare and drug discovery. Her research contributions have been acknowledged by receiving awards from the NC3R’s, the Swiss Laboratory Animal Science Association, and the International Society for Applied Ethology.
Scientific Meetings
PSI Pre-Clinical SIG Webinar: Therioepistemology - Rethinking how we conduct animal-based experimentation
Date: Tuesday 4th October 2022 Time: 14:00-15:00 BST | 15:00-16:00 CEST Speaker: Brianna Gaskill (Novartis)
Who is this event intended for? Colleagues working in in-vivo research. What is the benefit of attending? Attendees have the opportunity to learn how knowledge can be gained from animal research.
Registration
You can now register for this event. Registration fees are as follows:
- Members of PSI = Free of charge
- Non-Members of PSI = Free of charge
To register for the session, please click here.
Overview
In recent years, the scientific community has finally become more generally aware of the current reproducibility and translatability crisis. Some of this awareness has come from the recent NIH initiative on “Enhancing rigor, transparency, and translatability in animal research” starting a paradigm shift around certain themes. This shift can be characterized at the micro level as a shift from asking “what have we controlled for in this model?” to asking “what have we chosen to ignore in this model, and at what cost?” At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study, this includes providing for an animals welfare as well as experimental design and analysis techniques. Colleagues and I feel that we are witnessing the birth of a new discipline, which we have termed Therioepistemology, or the study of how knowledge is gained from animal research. In this talk, I’ll outline six questions that help critically evaluate animal-based biomedical research from a therioepistemological perspective. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health, animal well-being, and scientific quality.
Speaker details
Speaker
Biography
Brianna Gaskill, PhD Novartis
Brianna received her BS from Kansas State University and PhD in Animal Behavior and Well-being from Purdue University. She completed a postdoctoral position at Charles River after graduation, then returned to Purdue as a faculty member in 2014 and was awarded tenure in 2020. Her research has focused on developing new animal welfare assessment methodologies, rodent well-being, and elucidating the scientific impact of welfare problems in animal based research. She recently started a new position at Novartis as their 3Rs scientist where she will work closely with disease area scientists to apply 3Rs strategies to improve animal welfare and drug discovery. Her research contributions have been acknowledged by receiving awards from the NC3R’s, the Swiss Laboratory Animal Science Association, and the International Society for Applied Ethology.
Training Courses
PSI Pre-Clinical SIG Webinar: Therioepistemology - Rethinking how we conduct animal-based experimentation
Date: Tuesday 4th October 2022 Time: 14:00-15:00 BST | 15:00-16:00 CEST Speaker: Brianna Gaskill (Novartis)
Who is this event intended for? Colleagues working in in-vivo research. What is the benefit of attending? Attendees have the opportunity to learn how knowledge can be gained from animal research.
Registration
You can now register for this event. Registration fees are as follows:
- Members of PSI = Free of charge
- Non-Members of PSI = Free of charge
To register for the session, please click here.
Overview
In recent years, the scientific community has finally become more generally aware of the current reproducibility and translatability crisis. Some of this awareness has come from the recent NIH initiative on “Enhancing rigor, transparency, and translatability in animal research” starting a paradigm shift around certain themes. This shift can be characterized at the micro level as a shift from asking “what have we controlled for in this model?” to asking “what have we chosen to ignore in this model, and at what cost?” At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study, this includes providing for an animals welfare as well as experimental design and analysis techniques. Colleagues and I feel that we are witnessing the birth of a new discipline, which we have termed Therioepistemology, or the study of how knowledge is gained from animal research. In this talk, I’ll outline six questions that help critically evaluate animal-based biomedical research from a therioepistemological perspective. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health, animal well-being, and scientific quality.
Speaker details
Speaker
Biography
Brianna Gaskill, PhD Novartis
Brianna received her BS from Kansas State University and PhD in Animal Behavior and Well-being from Purdue University. She completed a postdoctoral position at Charles River after graduation, then returned to Purdue as a faculty member in 2014 and was awarded tenure in 2020. Her research has focused on developing new animal welfare assessment methodologies, rodent well-being, and elucidating the scientific impact of welfare problems in animal based research. She recently started a new position at Novartis as their 3Rs scientist where she will work closely with disease area scientists to apply 3Rs strategies to improve animal welfare and drug discovery. Her research contributions have been acknowledged by receiving awards from the NC3R’s, the Swiss Laboratory Animal Science Association, and the International Society for Applied Ethology.
Journal Club
PSI Pre-Clinical SIG Webinar: Therioepistemology - Rethinking how we conduct animal-based experimentation
Date: Tuesday 4th October 2022 Time: 14:00-15:00 BST | 15:00-16:00 CEST Speaker: Brianna Gaskill (Novartis)
Who is this event intended for? Colleagues working in in-vivo research. What is the benefit of attending? Attendees have the opportunity to learn how knowledge can be gained from animal research.
Registration
You can now register for this event. Registration fees are as follows:
- Members of PSI = Free of charge
- Non-Members of PSI = Free of charge
To register for the session, please click here.
Overview
In recent years, the scientific community has finally become more generally aware of the current reproducibility and translatability crisis. Some of this awareness has come from the recent NIH initiative on “Enhancing rigor, transparency, and translatability in animal research” starting a paradigm shift around certain themes. This shift can be characterized at the micro level as a shift from asking “what have we controlled for in this model?” to asking “what have we chosen to ignore in this model, and at what cost?” At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study, this includes providing for an animals welfare as well as experimental design and analysis techniques. Colleagues and I feel that we are witnessing the birth of a new discipline, which we have termed Therioepistemology, or the study of how knowledge is gained from animal research. In this talk, I’ll outline six questions that help critically evaluate animal-based biomedical research from a therioepistemological perspective. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health, animal well-being, and scientific quality.
Speaker details
Speaker
Biography
Brianna Gaskill, PhD Novartis
Brianna received her BS from Kansas State University and PhD in Animal Behavior and Well-being from Purdue University. She completed a postdoctoral position at Charles River after graduation, then returned to Purdue as a faculty member in 2014 and was awarded tenure in 2020. Her research has focused on developing new animal welfare assessment methodologies, rodent well-being, and elucidating the scientific impact of welfare problems in animal based research. She recently started a new position at Novartis as their 3Rs scientist where she will work closely with disease area scientists to apply 3Rs strategies to improve animal welfare and drug discovery. Her research contributions have been acknowledged by receiving awards from the NC3R’s, the Swiss Laboratory Animal Science Association, and the International Society for Applied Ethology.
Webinars
PSI Pre-Clinical SIG Webinar: Therioepistemology - Rethinking how we conduct animal-based experimentation
Date: Tuesday 4th October 2022 Time: 14:00-15:00 BST | 15:00-16:00 CEST Speaker: Brianna Gaskill (Novartis)
Who is this event intended for? Colleagues working in in-vivo research. What is the benefit of attending? Attendees have the opportunity to learn how knowledge can be gained from animal research.
Registration
You can now register for this event. Registration fees are as follows:
- Members of PSI = Free of charge
- Non-Members of PSI = Free of charge
To register for the session, please click here.
Overview
In recent years, the scientific community has finally become more generally aware of the current reproducibility and translatability crisis. Some of this awareness has come from the recent NIH initiative on “Enhancing rigor, transparency, and translatability in animal research” starting a paradigm shift around certain themes. This shift can be characterized at the micro level as a shift from asking “what have we controlled for in this model?” to asking “what have we chosen to ignore in this model, and at what cost?” At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study, this includes providing for an animals welfare as well as experimental design and analysis techniques. Colleagues and I feel that we are witnessing the birth of a new discipline, which we have termed Therioepistemology, or the study of how knowledge is gained from animal research. In this talk, I’ll outline six questions that help critically evaluate animal-based biomedical research from a therioepistemological perspective. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health, animal well-being, and scientific quality.
Speaker details
Speaker
Biography
Brianna Gaskill, PhD Novartis
Brianna received her BS from Kansas State University and PhD in Animal Behavior and Well-being from Purdue University. She completed a postdoctoral position at Charles River after graduation, then returned to Purdue as a faculty member in 2014 and was awarded tenure in 2020. Her research has focused on developing new animal welfare assessment methodologies, rodent well-being, and elucidating the scientific impact of welfare problems in animal based research. She recently started a new position at Novartis as their 3Rs scientist where she will work closely with disease area scientists to apply 3Rs strategies to improve animal welfare and drug discovery. Her research contributions have been acknowledged by receiving awards from the NC3R’s, the Swiss Laboratory Animal Science Association, and the International Society for Applied Ethology.
Careers Meetings
PSI Pre-Clinical SIG Webinar: Therioepistemology - Rethinking how we conduct animal-based experimentation
Date: Tuesday 4th October 2022 Time: 14:00-15:00 BST | 15:00-16:00 CEST Speaker: Brianna Gaskill (Novartis)
Who is this event intended for? Colleagues working in in-vivo research. What is the benefit of attending? Attendees have the opportunity to learn how knowledge can be gained from animal research.
Registration
You can now register for this event. Registration fees are as follows:
- Members of PSI = Free of charge
- Non-Members of PSI = Free of charge
To register for the session, please click here.
Overview
In recent years, the scientific community has finally become more generally aware of the current reproducibility and translatability crisis. Some of this awareness has come from the recent NIH initiative on “Enhancing rigor, transparency, and translatability in animal research” starting a paradigm shift around certain themes. This shift can be characterized at the micro level as a shift from asking “what have we controlled for in this model?” to asking “what have we chosen to ignore in this model, and at what cost?” At the macro level, it is a shift from viewing animals as tools (the furry test tube), to viewing them as patients in an equivalent human medical study, this includes providing for an animals welfare as well as experimental design and analysis techniques. Colleagues and I feel that we are witnessing the birth of a new discipline, which we have termed Therioepistemology, or the study of how knowledge is gained from animal research. In this talk, I’ll outline six questions that help critically evaluate animal-based biomedical research from a therioepistemological perspective. Ultimately, by formalizing therioepistemology as a discipline, we can begin to discuss best practices that will improve the reproducibility and translatability of animal-based research, with concomitant benefits in terms of human health, animal well-being, and scientific quality.
Speaker details
Speaker
Biography
Brianna Gaskill, PhD Novartis
Brianna received her BS from Kansas State University and PhD in Animal Behavior and Well-being from Purdue University. She completed a postdoctoral position at Charles River after graduation, then returned to Purdue as a faculty member in 2014 and was awarded tenure in 2020. Her research has focused on developing new animal welfare assessment methodologies, rodent well-being, and elucidating the scientific impact of welfare problems in animal based research. She recently started a new position at Novartis as their 3Rs scientist where she will work closely with disease area scientists to apply 3Rs strategies to improve animal welfare and drug discovery. Her research contributions have been acknowledged by receiving awards from the NC3R’s, the Swiss Laboratory Animal Science Association, and the International Society for Applied Ethology.
Upcoming Events
Joint PSI/EFSPI Pre-Clinical SIG Webinar: Efficient R&D: SVEM and Advanced DOE in Preclinical Toxicity Testing
Date: Tuesday 8th October 2024
This 1-hour webinar will be an opportunity to hear how JMP have been influential in the toxicity testing of an oncology formulation in a pre-clinical setting. At the end of the presentation there will also be the opportunity to ask questions.
Joint PSI/EFSPI Visualisation SIG 'Wonderful Wednesday' Webinars
Date: The Second Wednesday of every Month
Our monthly webinar explores examples of innovative data visualisations relevant to our day to day work. Each month a new dataset is provided from a clinical trial or other relevant example, and participants are invited to submit a graphic that communicates interesting and relevant characteristics of the data.
Joint PSI/EFSPI Small Populations & RWD SIG Webinar: Harnessing Real-World Data (RWD) in clinical trials for small populations and rare diseases
Date: Thursday 17th October 2024
In this webinar we will review the range of statistical methodologies used to harness the potential of Real-World Data (RWD) in clinical development, particularly in the context of rare diseases and small populations like paediatrics. The session will include theoretical understanding and practical case studies, with a special focus on Bayesian methods and causal inference.
Date: Wednesday 23rd October 2024
In this event, we’ll start with a general introduction to hierarchical composite endpoints and an overview of common analysis methods including win ratio, win odds, and net benefit. Then, the practical considerations will be illustrated through case studies from clinical trials in heart failure and chronic kidney disease. We conclude with a discussion and a Q&A.
PSI Training Course: Introduction to Bayesian Methods
Dates:
Module 1 - Wednesday 20th November
Module 2 - Tuesday 26th November
Module 3 - Thursday 28th November
This interactive and hands on online course, aimed at beginner Bayesians who have little or no experience in Bayesian statistics, is split into 3 modules. Module 1 introduces Bayesian concepts and looks at how Bayes has been used recently in the Pharmaceutical Industry, and participants will undertake their own data collection exercise in order to analyse a simple Bayesian trial. Module 2 takes a look at the concepts of Bayesian statistics and key terminology and provides a chance to analyse some data using a simple Bayesian approach. Module 3 takes a further look at the use of Bayesian statistics in drug development and regulatory requirements and digs deeper into analysis issues.
Date: 20 October 2024
This event is aimed at students with an interest in the field of Medical Statistics, for example within pharmaceuticals, healthcare and/or medical research.
Joint PSI/EFSPI Pre-Clinical SIG Webinar: Virtual Control Groups in Toxicity Studies
Date: Re-scheduled to Tuesday 26th November 2024
Lea Vaas will present how replacement of concurrent control animals by Virtual Control Groups (VCGs) in systemic toxicity studies may help in contributing to the 3R's principle of animal experimentation: Reduce, Refine, Replace.
Date: Tuesday 10th December 2024
This networking event is aimed at statisticians that are new to the pharmaceutical industry who wish to meet colleagues from different companies and backgrounds.
PSI Introduction to Industry Training (ITIT) Course - 2024/2025
Date: October 2024 - July 2025
An introductory course giving an overview of the pharmaceutical industry and the drug development process as a whole, aimed at those with 1-3 years' experience. It comprises of six 2-day sessions covering a range of topics including Research and Development, Toxicology, Data Management and the Role of a CRO, Clinical Trials, Reimbursement, and Marketing.
Senior Medical Statistician & Statistical Programmer
An exciting opportunity has arisen for a Senior Medical Statistician & Statistical Programmer to join the UKCRC fully registered Derby Clinical Trials Support Unit (Derby CTSU).