Tuesday 19th September 2017
2:00-3:00 pm (UK Time)
(Organised by the Toxicology Special Interest Group)
Presenter: David Lovell, St George’s Medical School, University of London
The bacterial reverse mutation assay (or the Ames test) has been in use in its present form for over 40 years. It is arguably the most successful in vitro test, used by hundreds of laboratories worldwide, on thousands of substances. The test aims to identify substances that can produce genetic damage and may lead to cancer in exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tests have been proposed for the analysis of the data produced. Interpretation of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretation. Ames test results are also used in helping to develop in silico methods for predicting carcinogenicity.
This presentation will illustrate these issues and also discuss newer versions of the test and the continuing assessment of the role of the test in toxicology.
Tuesday 19th September 2017
2:00-3:00 pm (UK Time)
(Organised by the Toxicology Special Interest Group)
Presenter: David Lovell, St George’s Medical School, University of London
The bacterial reverse mutation assay (or the Ames test) has been in use in its present form for over 40 years. It is arguably the most successful in vitro test, used by hundreds of laboratories worldwide, on thousands of substances. The test aims to identify substances that can produce genetic damage and may lead to cancer in exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tests have been proposed for the analysis of the data produced. Interpretation of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretation. Ames test results are also used in helping to develop in silico methods for predicting carcinogenicity.
This presentation will illustrate these issues and also discuss newer versions of the test and the continuing assessment of the role of the test in toxicology.
Tuesday 19th September 2017
2:00-3:00 pm (UK Time)
(Organised by the Toxicology Special Interest Group)
Presenter: David Lovell, St George’s Medical School, University of London
The bacterial reverse mutation assay (or the Ames test) has been in use in its present form for over 40 years. It is arguably the most successful in vitro test, used by hundreds of laboratories worldwide, on thousands of substances. The test aims to identify substances that can produce genetic damage and may lead to cancer in exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tests have been proposed for the analysis of the data produced. Interpretation of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretation. Ames test results are also used in helping to develop in silico methods for predicting carcinogenicity.
This presentation will illustrate these issues and also discuss newer versions of the test and the continuing assessment of the role of the test in toxicology.
Tuesday 19th September 2017
2:00-3:00 pm (UK Time)
(Organised by the Toxicology Special Interest Group)
Presenter: David Lovell, St George’s Medical School, University of London
The bacterial reverse mutation assay (or the Ames test) has been in use in its present form for over 40 years. It is arguably the most successful in vitro test, used by hundreds of laboratories worldwide, on thousands of substances. The test aims to identify substances that can produce genetic damage and may lead to cancer in exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tests have been proposed for the analysis of the data produced. Interpretation of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretation. Ames test results are also used in helping to develop in silico methods for predicting carcinogenicity.
This presentation will illustrate these issues and also discuss newer versions of the test and the continuing assessment of the role of the test in toxicology.
Tuesday 19th September 2017
2:00-3:00 pm (UK Time)
(Organised by the Toxicology Special Interest Group)
Presenter: David Lovell, St George’s Medical School, University of London
The bacterial reverse mutation assay (or the Ames test) has been in use in its present form for over 40 years. It is arguably the most successful in vitro test, used by hundreds of laboratories worldwide, on thousands of substances. The test aims to identify substances that can produce genetic damage and may lead to cancer in exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tests have been proposed for the analysis of the data produced. Interpretation of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretation. Ames test results are also used in helping to develop in silico methods for predicting carcinogenicity.
This presentation will illustrate these issues and also discuss newer versions of the test and the continuing assessment of the role of the test in toxicology.
Tuesday 19th September 2017
2:00-3:00 pm (UK Time)
(Organised by the Toxicology Special Interest Group)
Presenter: David Lovell, St George’s Medical School, University of London
The bacterial reverse mutation assay (or the Ames test) has been in use in its present form for over 40 years. It is arguably the most successful in vitro test, used by hundreds of laboratories worldwide, on thousands of substances. The test aims to identify substances that can produce genetic damage and may lead to cancer in exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tests have been proposed for the analysis of the data produced. Interpretation of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretation. Ames test results are also used in helping to develop in silico methods for predicting carcinogenicity.
This presentation will illustrate these issues and also discuss newer versions of the test and the continuing assessment of the role of the test in toxicology.
Joint PSI/EFSPI Visualisation SIG 'Wonderful Wednesday' Webinars
Our monthly webinar explores examples of innovative data visualisations relevant to our day to day work. Each month a new dataset is provided from a clinical trial or other relevant example, and participants are invited to submit a graphic that communicates interesting and relevant characteristics of the data.
PSI Webinar: Development of Gene Therapies: Strategic, Scientific, Regulatory and Access Considerations
This webinar will cover the history of cell/gene therapy, major regulatory advances, the role of quantitative scientists in drug development of these novel therapeutics, and discuss opportunities for innovation and product advancement.
This networking event is aimed at statisticians that are new to the pharmaceutical industry who wish to meet colleagues from different companies and backgrounds.
PSI Introduction to Industry Training (ITIT) Course - 2024/2025
An introductory course giving an overview of the pharmaceutical industry and the drug development process as a whole, aimed at those with 1-3 years' experience. It comprises of six 2-day sessions covering a range of topics including Research and Development, Toxicology, Data Management and the Role of a CRO, Clinical Trials, Reimbursement, and Marketing.
PSI Training Course: Regulatory Guidelines for Statisticians
This 2-day course is designed to provide a comprehensive understanding of the regulatory guidelines affecting statisticians in the pharmaceutical industry, including the latest updates in the field. The course will cover key International Council for Harmonisation (ICH) guidelines and other key regional regulatory agency documents.
Joint PSI/EFSPI Pre-Clinical SIG Webinar: Virtual Control Groups in Toxicity Studies
Lea Vaas will present how replacement of concurrent control animals by Virtual Control Groups (VCGs) in systemic toxicity studies may help in contributing to the 3R's principle of animal experimentation: Reduce, Refine, Replace.
This networking event is aimed at statisticians that are new to the pharmaceutical industry who wish to meet colleagues from different companies and backgrounds.
This apprenticeship role offers a unique opportunity to learn and work in a global healthcare consultancy company alongside a team of statisticians, psychometricians and programmers.
Statisticians in the Pharmaceutical Industry Executive Office: c/o MCI UK Ltd | Unit 24/22 South | Building 4000 | Langstone Park| Langstone Road | Havant | PO9 1SA | UK