PSI Conference Webinar: PSI/RSS Prize Winners Session

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Date: Thursday 11th June 2020
Time: 10:00 - 11:00
Speakers: Mike Smith (Pfizer) and Jacquie Christie (GSK) 


This webinar is part of our 2020 Conference Webinar Series. Further information including details of other webinars that are included in the Conference package can be found here.
Members receive all webinars in the conference series for free.
Non-members receive all webinars in the conference series for £100+VAT, which includes complimentary membership* of PSI until the 31st December 2020.

To register your place for this event, and others in the Conference webinar series, please click here.

Speaker Details:



Session Abstract

Mike Smith,

Mike K Smith has worked in a variety of roles at Pfizer for over 26 years. He is a currently a Senior Director in Statistics providing specialist computation and modelling solutions to projects, evaluating and deploying new tools. He is an RStudio certified tidyverse trainer and a professional R geek. He was previously in a similar role for the pharmacometrics modelling and simulation group within clinical pharmacology at Pfizer. During this time he worked on the IMI DDMoRe project, delivering a novel model description language for pharmacometric models. He is the author or collaborator on many manuscripts pertaining to model-informed drug development, modelling and simulation and implementation of tools and workflows to assist with these.

What is innovation? How do I innovate? Is it a skill that I can learn or improve on? In this presentation I will attempt to define what I mean by innovation and break down what I consider to be drivers of innovation. Some of these are things that you CAN definitely work on. It is true that some are environmental or cultural but even these are things that you can influence or change. I will illustrate how these elements have come together to help me and my colleagues deliver on projects, innovate and break out of “tried and tested” methods, including those cited in my RSS/PSI Statistical Excellence in the Pharmaceutical Industry award.

Jacquie Christie 
Jacquie Christie has 25 years’ experience as a biostatistician in the pharmaceutical industry.Her current position is Therapeutic Area Biostatistics Head for Immunology & Inflammation, in which she has overall responsibility for statistical activities relating to clinical development, from phase 1 through to lifecycle management. She has been in this role for over 10 years, and in that time has supported numerous projects in a wide range ofimmune mediated diseases.She has previously held roles as Biostatistics Head for Neurology Drug Discovery and for GSK’s Biopharmaceuticals unit. Quantitative Decision-Making for Clinical Development.

Low productivity and late-stage attrition are well-known pharmaceutical R&D problems; one cause is poor decision-making at key milestones.Failure to consider the impact of current design choices on future investment options increases uncertainty when the decision-point arrives, and consequently increases the risk of a wrong decision. 
This talk will outline an approach to quantitative decision-making in a completely Bayesian setting.Prior distributions are used to evaluate proposed study designs and decision rules against not only the probability of success of the current study, but that of the subsequent study or set of studies.Termination and progression criteria and associated risks are then clear, allowing more informed decision-making. The approach is applicable to all phases of R&D.


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