Time: 14:00 - 15:00 UK Time Presenter: Dr Bernd-Wolfgang Igl
Dr Bernd-Wolfgang Igl, Principal Statistician at Bayer, will be presenting on Statistical Analysis of the Comet-Assay.
Dr Bernd-Wolfgang Igl
Statistical Analysis of the Comet assay
Research and Clinical Sciences Statistics, Bayer AG, Berlin, Germany
The single cell gel electrophoresis assay, also known as Comet assay, is a widespread test within genetic toxicology and sensitive to detect chemically induced DNA damages in various tissues. This webinar will start with an introduction to the toxicological background and the test principle itself, including a description of the standard experimental design. Different statistical strategies will then be presented; the focus will be on the in-vivo Comet assay. Finally, the use of median instead of average tail intensities per slide will be described and discussed; this is suggested in the updated OECD Guideline for the Testing of Chemicals No. 489, thus directly affecting the statistical analysis.
PSI, the European Federation of Statisticians in the Pharmaceutical Industry (EFSPI) and the Biopharmaceutical Section of the American Statistical Association (ASA) are jointly organising a webinar on Estimands in Practice. Speakers from regulatory authorities (FDA and EMA) and industry will present on their experience on this topic to date.
Discover your potential by working as a Covance Senior Principal / Principal Biostatistician. You'll enjoy a varied role working for different sponsors across several therapeutic areas, leading projects and mentoring junior members of the department.
Biometrics at AstraZeneca provides the data that influences decisions on how we roll back the frontiers of science to bring life-changing medicines to the world. We are at the heart of design, analytics and interpretation of AstraZeneca’s portfolio.