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03 October 2023

Satrajit Roychoudhury, Kenneth Koury, Sebastian Weber, Emma Clark.

The use of Bayesian methods within clinical development has greatly increased in recent years. This is particularly true for earlier stage trials but they are also being used in later stage work. In this webinar, three different examples of where Bayesian methodology has been used within confirmatory settings will be provided.

The examples describe: A Bayesian framework used to incorporate several interim analyses to monitor the trial for efficacy and futility, while controlling the overall type 1 error. Use of the meta-analytic-predictive prior methodology, interpreting study data in the context of trial external data while accounting for between-trial heterogeneity. Incorporating a hybrid external control arm using Bayesian dynamic borrowing with propensity score matching. 

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