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Joint PSI/EFSPI Pre-Clinical SIG Webinar: OMARS Designs: Factor Screening and Response Surface Optimization in a Single Step

26 March 2024

Peter Goos

The family of orthogonal minimally aliased response surface designs or OMARS designs bridges the gap between small definitive screening designs and classical response surface designs, such as central composite and Box-Behnken designs. The initial OMARS designs involve three levels per factor and large numbers of quantitative factors to be studied efficiently using limited numbers of experimental tests. Many of the OMARS design possess good projection properties and offer better powers for quadratic effects than definitive screening designs with similar numbers of runs. Therefore, OMARS designs offer the possibility to perform a screening experiment and a response surface experiment in a single step, and thereby offer the opportunity to speed up innovation and process improvement. A technical feature of the initial OMARS designs is that they study every quantitative factor at its middle level the same number of times. In this talk, we relax this constraint and arrange the designs in blocks, and thereby broaden the family of OMARS designs, presenting application of OMARS designs in pharmaceutical and chemical industries. 

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