VIS-SIG Blog

VIS-SIG Blog

Wonderful Wednesdays May 2024

Study flow charts
Wonderful Wednesdays

In almost every study there is a flow chart to present the patient's path through the trial. What could the next level of study flow charts look like? Sandard study flow charts are basically organised lookup tables. A true visualisation can do much more. For example colour coding or indenting boxes can help organising. Also additional information can be embedded. This can easily done in R. For patient disposition Sankey diagrams can be extremely useful. This is even more powerful if used interactively. People charts even go without explanation.

Wonderful Wednesdays April 2024

Power Calculations
Wonderful Wednesdays

As statisticians, we often have to deal with power or sample size calculations. It can be very beneficial to visualise the impact that different factors have on the sample size or power. Produce data visualisation(s) or share tools that help your audience understand how power and sample size calculations work and what impacts the actual results of these calculations.

Wonderful Wednesdays March 2024

Microbiome
Wonderful Wednesdays

Produce data visualisation(s) providing insights into how microbiome profiles change over time and what the differences are in microbiome profiles between Pre-Term Birth and Term Birth.

Wonderful Wednesdays February 2024

Wonderful Wednesdays

Find a plot in a healthcare related publication and improve the visual presentation with only the data available from the publication.

Wonderful Wednesdays January 2024

Wonderful Wednesdays

Best of 2023

Wonderful Wednesdays December 2023

Demographic data display
Wonderful Wednesdays

Demographic data display: The challenge is based on CDISC data. It is a standard ADSL data set for subject level data (demographics and baseline).

Wonderful Wednesdays November 2023

Gatekeeping Procedure
Wonderful Wednesdays

Gatekeeping Procedure: Results are provided from a simulation of a phase III study in schizophrenia patients, investigating efficacy at 3 dose levels (Low, Medium, High) versus placebo. The study includes a primary endpoint and two key secondary endpoints. The study includes a total of 9 hypotheses, and multiplicity adjustments are required to control for type I error.

Wonderful Wednesdays October 2023

data cleaning
visual analytics
Wonderful Wednesdays

Leverage visual analytics to identify data issues.

Wonderful Wednesdays September 2023

Treatment effect
Wonderful Wednesdays

The PRIMUM study aimed to improve medication appropriateness in elderly patients with multimorbidity. A complex intervention involving general practitioners (GPs) and their healthcare assistants (HCA) was developed and compared to usual care. Check for a treatment effect on the MAI score after the intervention. Visualize the effect of adjusting the treatment effect for the MAI score at baseline.

Wonderful Wednesdays August 2023

Benefit-Risk Assessment
Wonderful Wednesdays

Benefit-Risk Assessment: For a drug to be approved for marketing, regulatory authorities must determine that the drug is effective and that its expected benefits outweigh its potential risks to patients. An Alzheimer’s Disease drug might have a positive benefit-risk profile for lowering blood pressure. To generate a hypothesis, an exploratory benefit-risk assessment will be conducted.

Wonderful Wednesdays July 2023

US Disease Incidence
Epidemiology data
Wonderful Wednesdays

US Disease Incidence

Visualisation SIG Showcase

PSI conference
Visualisation SIG Showcase

This is an entry accompanying the poster at the PSI conference 2023.

Wonderful Wednesdays May 2023

Clinical Global Impression (CGI)
Wonderful Wednesdays

Data visualisations to present Clinical Global Impression Data and to provide comparisons between the different groups (e.g. based on response differences or odds ratios for the different response categories).

Wonderful Wednesdays April 2023

Diary Data
Wonderful Wednesdays

This month’s challenge will be to visualise diary data, whereby patients complete a diary (grading a number of symptoms), each day. For this challenge, we consider a hypothetical diary, consisting of 6 symptoms (Exhaustion, Aching, Tenderness, Depression, Loneliness, Anxiety). 300 subjects (200 active, 100 placebo), grade each of these symptoms on a 4-point scale (0 = None, 1 = Minor, 2 = Moderate, 3 = Extreme) each day, for 100 days.

Wonderful Wednesdays March 2023

DLQI
Wonderful Wednesdays

This month’s challenge was to improve a published visualisation. The visualisation displayed the mean (and SD) Dermatology Life Quality Index (DLQI) score for 12 studies on alopecia areata. The publication had visualised these using ‘dynamite plots’, a type of visualisation which has received criticism in the past.

Wonderful Wednesdays December 2022

VAERS
Wonderful Wednesdays

The data is an excerpt of the official VAERS data created by US Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) that may be associated with vaccines.

Wonderful Wednesdays November 2022

Quality of life
Missing data
Wonderful Wednesdays

The EORTC QLQ-C30 is a 30-item questionnaire that has been designed for use in a wide range of cancer patient populations and is a reliable and valid measure of the quality of life in cancer patients. It includes a number of different scales, but this challenge is focussed on the global health and quality of life scale (QL).

Wonderful Wednesdays October 2022

Quality of life
Wonderful Wednesdays

The EORTC QLQ-C30 is a 30-item questionnaire that has been designed for use in a wide range of cancer patient populations and is a reliable and valid measure of the quality of life in cancer patients (Aaronson et al., 1993).

Wonderful Wednesdays September 2022

EQ-5D
Predictors
Wonderful Wednesdays

The data is based on a study to assess the health status in patients with coronary heart diseases (see Ose et al., 2012). The research question was: what factors are associated with health status in usual primary care? The original data included 2,656 patients with 14 (patient and practice) characteristics (with clustered data structure). The outcome was EQ-5D VAS scale (Health related quality of life; range: [0; 1]). The data set for this challenge is a sub-sample of patients and variables and it is simulated data.

Wonderful Wednesdays August 2022

Ranking Data
Wonderful Wednesdays

Visualise the relative performance of the treatments based on ranking data. You may want to consider other metrics which can be derived from the ranking data and used to compare treatments.

Wonderful Wednesdays July 2022

Patient profiles
Wonderful Wednesdays

Detailed patient level data is meant to be an informed representation of the patient and what happened to the patient during the course of the study. These visualisations can help to get a quick overview on demographic information as well as exposure, concomitant medications, adverse events and laboratory data.

Wonderful Wednesdays June 2022

Pediatric Growth
Wonderful Wednesdays

The purpose of this data visualization is to assess if there is an adverse impact on the growth of these children due to taking the drug (exploratory). Explanatory examples are welcome too (once you know the answer).

Wonderful Wednesdays May 2022

HiSCR
Combined endpoint
Wonderful Wednesdays

The challenge is to visualize the impact of changing the definition of HiSCR response on the results. The idea is to change, for example, the first condition and assume that a decrease of 25% or 75% is needed to reach HiSCR response. The second and third condition can be changed separately, or a mix of changes to two or all conditions can be applied. How does this impact the results?

Wonderful Wednesdays April 2022

OSCI
Data over time
Wonderful Wednesdays

The data reflects a phase III study - active vs placebo and the endpoint was Ordinal Scale for Improvement (OSCI). All patients started at OSCI=4 and daily measures over 35 days were performed. The challenge was to describe the treatment effect specifically taking into account the number and timing of patients who died, left the hospital or fully recovered.