PSI Journal Club: Limitations and Challenges with Mixed Model Repeated Measures (MMRM) Analysis
Moses Mwangi and Florian Lasch present their recent work on MMRM, with discussion lead by Geert Molenberghs.
A summary of each activity is given below. Full instructions plus worksheets and other paper materials can be downloaded by clicking on the icon.
Objectives: Pupils will learn how to collect and collate their own data and will explore statistical and practical considerations which arise in designing experiments.
Run time: 30 min (30 min prep)
Equipment required: Smarties, calculators and a black/white board or flip chart for collating results
Objectives: To give an interactive example of how statistics can be used to test relationships between categorical variables and introduce the placebo effect and the importance of blinding a trial (concealing treatment allocation).
Run time: 45 min (20 min prep)
Equipment required:
Run time: 45 min (10 min prep)
Equipment required:
Objectives: To introduce the students to National Institute for Health and Clinical Excellence (NICE) and make them think about the decisions that go into putting new drugs on the market. Groups need to decide which drug out of three they would choose to make available for use in the UK.
Run time: 45 min (10 min prep)
Equipment: A laptop and projector for slides
Run time: 45 min (40 min prep)
Equipment required: paperclips, stopwatch , scissors and labelled envelopes to hold pack 1 and 2 materials separately.
Objectives: To introduce the concept of ‘Regression to the Mean’ along with some good principles of clinical trial design such as the use of controls and avoidance of bias. Advanced students can cover analysing results using a Chi Square test.
Run time: 45 min (15 min prep)