BEGIN:VCALENDAR VERSION:2.0 METHOD:PUBLISH PRODID:-//Telerik Inc.//Sitefinity CMS 13.3//EN BEGIN:VTIMEZONE TZID:UTC BEGIN:STANDARD DTSTART;VALUE=DATE:20230101 TZNAME:UTC TZOFFSETFROM:+0000 TZOFFSETTO:+0000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DESCRIPTION:Tuesday 19th \;September 2017\n2:00-3:00 pm (UK Time)\n\n(O rganised by the Toxicology Special Interest Group)\nPresenter: David Lovel l\, St George&rsquo\;s Medical School\, University of London\n\nThe bacter ial reverse mutation assay (or the Ames test) has been in use in its prese nt form for over 40 years. It is arguably the most successful in vitro tes t\, used by hundreds of laboratories worldwide\, on thousands of substance s. The test aims to identify substances that can produce genetic damage an d may lead to cancer in exposed individuals or to inherited mutation in of fspring to cancer.\nThe design of the test is basically simple and numerou s statistical tests have been proposed for the analysis of the data produc ed. Interpretation of the result aims at categorizing the chemical as eith er a genotoxin or a non-genotoxin. This provides an interesting example of the contrast between statistical significance and biological interpretati on. Ames test results are also used in helping to develop in silico method s for predicting carcinogenicity.\nThis presentation will illustrate these issues and also discuss newer versions of the test and the continuing ass essment of the role of the test in toxicology.\nTo access the recording\, please visit the Video-on-Demand Library. DTEND:20170919T150000Z DTSTAMP:20240328T093302Z DTSTART:20170919T140000Z LOCATION: SEQUENCE:0 SUMMARY:PSI Webinar: Statistics and the Ames Test UID:RFCALITEM638472151822114396 X-ALT-DESC;FMTTYPE=text/html:
Tuesda
y 19th \;September 2017
\n
2:00-3:00 pm (UK Time)
\n
(Organised by the Toxicology Special Interest Group) p>\n
Presenter: David Lovell\, St George&rsquo\;s Medical School\, Unive
rsity of London
\n
\nThe bacterial reverse mutation assay (or th
e Ames test) has been in use in its present form for over 40 years. It is
arguably the most successful in vitro test\, used by hundreds of
laboratories worldwide\, on thousands of substances. The test aims to iden
tify substances that can produce genetic damage and may lead to cancer in
exposed individuals or to inherited mutation in offspring to cancer.
The design of the test is basically simple and numerous statistical tes ts have been proposed for the analysis of the data produced. Interpretatio n of the result aims at categorizing the chemical as either a genotoxin or a non-genotoxin. This provides an interesting example of the contrast bet ween statistical significance and biological interpretation. Ames test res ults are also used in helping to develop in silico methods for pr edicting carcinogenicity.
\nThis presentation will illustrate these issues and also discuss newer versions of the test and the continuing asse ssment of the role of the test in toxicology.
\nTo access th e recording\, please visit the Video-on-D emand Library.
END:VEVENT END:VCALENDAR